Cefixime & Ofloxacin Tablets

Composition

Each Film Coated Tablet Contains: Cefixime Trihydrate Eq. to Anhydrous Cefixime Ofloxacin Excipients Approved color used :	IP IP	100 mg 100 mg q.s
Each Film Coated Tablet Contains: Cefixime Trihydrate Eq. to Anhydrous Cefixime Ofloxacin Excipients Approved color used :	IP IP	200 mg 200 mg q.s

Quick Facts About Cefixime & Ofloxacin Combination :

Effective Against : A wide range of bacterial infections, including UTIs, respiratory, and sexually transmitted infections.

Uses : Treats infections caused by both Gram-positive and Gram-negative bacteria.

Administration : Oral tablet for convenient at-home treatment.

Time to Relief : Typically provides relief within 24-48 hours for respiratory infections and 3-5 days for urinary tract infections.

Why Choose Cefixime & Ofloxacin Combination?

Broad-Spectrum : Targets both gram-positive and gram-negative bacteria for comprehensive infection treatment.
Convenient : Oral tablets allow for easy, at-home use without the need for injections.
Effective Synergy : The combination enhances treatment effectiveness, tackling a wide variety of infections
Fast-Acting : Provides rapid relief, typically within 24-48 hours for respiratory and 3-5 days for urinary tract infections.

Description :

Cefixime & Ofloxacin belongs to a class of medications called antibiotics. Specifically, it is a combination of a cephalosporin (Cefixime) and a fluoroquinolone (Ofloxacin), both of which are used for the treatment of a wide range of bacterial infections. These infections include those affecting the skin, ears, lungs, prostate, and urinary tract. In addition, this combination therapy is effective in treating conditions like typhoid fever and sexually transmitted diseases (STDs) such as chlamydia and gonorrhoea.

What is a Bacterial Infection?

A bacterial infection occurs when harmful bacteria enter the body, multiply, and release toxins that can damage tissues and disrupt normal bodily functions. These infections can lead to various diseases, including :

• Strep throat
• Urinary tract infections (UTI)
• Bacterial food poisoning
• Gonorrhoea
• Bacterial meningitis
• Cellulitis
• Lyme disease
• Tetanus

However, Cefixime + Ofloxacin is ineffective against viral infections, such as the flu and common cold. These infections are caused by viruses, not bacteria, and require different treatments.

Bacterial Infections Treated with Cefixime + Ofloxacin

The combination of Cefixime + Ofloxacin is highly effective against a variety of bacterial infections, including :

• Skin Infection : Such as cellulitis, impetigo, and abscesses.
• Ear Infection : Such as otitis media (middle ear infection).
• Lung Infection : Including pneumonia and bronchitis.
• Prostate Infection : Like prostatitis.
• Urinary Tract Infection (UTIs) : Affecting the kidneys, bladder and urethra.
• Typhoid Fever : Caused by Salmonella Bacteria.
• Sexually Transmitted Diseases (STD) : Including chlamydia and Gonorrhea.

Mechanism of Action :

The combination of Cefixime (a cephalosporin antibiotic) and Ofloxacin (a fluoroquinolone antibiotic) works by targeting different mechanisms within the bacterial cell to prevent their survival and multiplication :

• Cefixime : interferes with the synthesis of the bacterial cell wall. This structure is crucial for bacterial survival and without it, the bacteria become unstable and die.
• Ofloxacin : inhibits the bacteria’s ability to replicate DNA, which prevents further bacterial reproduction.

Together, these antibiotics prevent the formation of the bacterial cell wall and disrupt other essential processes, weakening and ultimately destroying the bacteria. This makes Cefixime + Ofloxacin a broad-spectrum antibiotic effective against both gram-positive and gram-negative bacteria.

Contraindications :

It is contraindicated in patients with a history of hypersensitivity to cefixime or/and ofloxacin.

Pharmacokinetic Properties :

Absorption :

• Cefixime : Well absorbed orally; peak plasma concentration occurs in 2-6 hours; food slightly delays absorption.
• Ofloxacin : Also well absorbed; peak plasma concentration occurs in 1-2 hours; food may slow absorption but doesn’t significantly affect overall absorption.

Distribution :

• Cefixime : Widely distributed in the body, including the lungs, middle ear, and urine; 65% protein-bound.
• Ofloxacin : Widely distributed in tissues, including the lungs, kidneys, and prostate; about 25-30% protein-bound.

Metabolism :

• Cefixime : Not extensively metabolized, primarily excreted unchanged in the urine.
• Ofloxacin : Partially metabolized in the liver; a large proportion remains unchanged.

Elimination :

• Cefixime : Excreted mainly unchanged in urine, with about 50% of the dose eliminated in 24 hours.
• Ofloxacin : Primarily excreted unchanged in urine, with a minor fraction eliminated in feces.

Half-Life :

• Cefixime: The half-life is typically 3-4 hours, but can extend up to 9 hours in some individuals.
• Ofloxacin: The half-life ranges from 4-7 hours.

Drug Interactions :

Always tell your healthcare provider about any prescription or OTC medicines, vitamins/minerals, herbal products and other supplements you are using. Avoid taking the following medications with Cefixime + Ofloxacin, as they may affect its safety and effectiveness :

• Antacids (e.g., magnesium hydroxide, aluminium hydroxide)
• Sucralfate
• Stomach acid reducers (e.g., cimetidine)
• Immunosuppressants (e.g., cyclosporine)
• Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) (e.g., ibuprofen, fenbufen)

Side-effects :

Common side-effects are :

• Nausea
• Diarrhea
• Vomiting
• Watery stools

Pregnancy and Breastfeeding :

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Driving and using machines :

You should be aware of how you react to Cefixime & Ofloxacin Tablets.
before, you drive or operate machinery. If you feel dizzy or drowsy after taking the tablet, do not drive or operate machinery until these effects wear off.

Dosage :

As Directed by the Physician.

Storage :

Store protected from moisture at a temperature not exceeding 30°C.
Keep the medicine out of reach of children.